Biosynthesis ofd-aspartate in mammalian cells1

Observation ofD D Oscillations

We report a measurement of the time-dependent ratio of D ! Kþ to D ! K þ decay rates in D þ-tagged events using 1:0 fb 1 of integrated luminosity recorded by the LHCb experiment. We measure the mixing parameters x02 1⁄4 ð 0:9 1:3Þ 10 , y0 1⁄4 ð7:2 2:4Þ 10 , and the ratio of doubly-Cabibbo-suppressed to Cabibbo-favored decay rates RD 1⁄4 ð3:52 0:15Þ 10 , where the uncertainties include statistic...

DNA-Protein Cross-Linking by Chemical Carcinogens in Mammalian Cells1

The induction of DNA cross-linking in mammalian cells by various carcinogens was investigated by the method of alkaline elution. A dose-dependent increase in DNA cross linking was seen following exposure of human fibroblasts to N-acetoxy-2-acetylaminofluorene and following expo sure of mouse embryo cells to 7,12-dimethylbenz[a]anthracene. No cross-link effect was seen following treat ment with ...

DNA Damage Induced by 193-nm Radiation in Mammalian Cells1

The contribution of DNA damage to the effects of 193-nm excimer laser radiation on mammalian cells in culture was studied in order to evaluate the mutagenic potential of this IV wavelength in vivo. Two approaches were taken: measurement of pyrimidine dimer-specific endonuclease-sensitive sites/megabase and comparison of the 193-nm ra diation-induced cytotoxicity in normal versus DNA repair-defi...

The orofaciodigital (OFD) syndromes.

Biosynthesis of mammalian DNA ligase.

A monospecific antibody against calf thymus DNA ligase composed of a single polypeptide with Mr = 130,000 cross-reacts with rodent and calf thymus DNA ligases. The antibody precipitates a single Mr = 200,000 polypeptide from detergent lysates of [3H] leucine-labeled mouse Ehrlich tumor cells and calf thymocytes. Pulse-chase experiments show that the Mr = 200,000 polypeptide in Ehrlich tumor cel...